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Microbiological effects of an antiseptic mouthrinse in irradiated cancer patients

机译：杀菌漱口水对癌症患者的微生物学作用

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Objective: To assess the microbiological effects of an antiseptic, non-alcohol based mouth-rinse containing chlorhexidine and cetylpyridinium chloride, in patients undergoing radiation therapy for head-and-neck cancer. Study Design: This was a parallel, double-blind, prospective, randomized clinical trial, including patients irradiated as part of the therapy of head-and-neck cancer, aged 18-75, with at least 10 teeth, and willing to sign an informed consent. Cancer patients were randomly assigned to one of the two treatments (test mouth-rinse or a placebo). Three visits were scheduled (baseline, 14 and 28 days). Microbiological findings were evaluated in tongue, mucosa and subgingival samples, by means of culture. Microbiological variables were assessed by means of the Mann-Whitney, Wilcoxon and chi-square tests. Results: 70 patients were screened and 36 were included. The detection of Candida species in mucosa and tongue samples showed significant reductions in the test group. Total bacterial counts decreased in both groups from baseline to the 2-week visit, while minor changes occurred between 2 and 4 weeks (effects on P. gingivalis, P. intermedia, C. rectus, E. corrodens). Conclusions: Within the limitations of the small sample size, this study suggests that the use of the tested mouth-rinse may lead to improvements in microbiological parameters in patients irradiated for head-and-neck cancer. © Medicina Oral S. L.
机译：目的：评估含洗必泰和十六烷基氯化吡啶鎓的无菌，无酒精防腐漱口液对头颈癌患者的放射治疗效果。研究设计：这是一项平行，双盲，前瞻性，随机临床试验，包括接受放射治疗的头颈癌患者，年龄在18-75岁之间，牙齿至少10颗，并且愿意签署知情同意。癌症患者被随机分配到两种治疗方法之一（测试漱口水或安慰剂）。安排了三次访问（基准，14天和28天）。通过培养评估舌头，粘膜和龈下样品中的微生物学发现。通过Mann-Whitney，Wilcoxon和卡方检验评估微生物学变量。结果：筛选了70例患者，其中36例被纳入。粘膜和舌头样品中念珠菌的检出率在测试组中显着降低。从基线到访问2周，两组的细菌总数均下降，而在2至4周之间发生细微变化（对齿龈假单胞菌，中间媒介假单胞菌，直肌假单胞菌，腐蚀大肠杆菌）。结论：在小样本量的限制内，这项研究表明，使用经测试的漱口水可能会导致接受头颈癌照射的患者的微生物学指标得到改善。 ©Medicina Oral S.L.

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